July 8th, 2020
Bruton’s tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of pro-inflammatory cytokines that can contribute to COVID‐19 immunopathology. Clinical trials with BTK inhibitors in COVID‐19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID‐19. We summarized the current knowledge of BTK/IL‐2‐inducible T‐cell kinase (ITK) signaling in immunopathology and lymphopenia and discuss the potential of BTK/ITK dual inhibitors in modulating immunopathology and lymphopenia, for COVID‐19 therapy. This frontline review is published today in Journal of Leukocyte Biology.
July 2nd, 2020
COVID-19 manifested multiple lines of symptoms, predominantly in the respiratory system. Mild COVID-19 patients however tend to suffer from neurological complications. In Wuhan, a number of COVID-19 patients developed neurologic manifestations. A long term of COVID-19 symptoms were observed in patients with milder respiratory manifestations, along with lower rate of virus-specific IgM/IgG sera conversion. Our retrospective epidemiological study was published today in MedComm.
May 27th, 2020
Glycyrrhetinic acid and its derivatives share a similar molecular structure with steroid, and have been shown with anti-viral and anti-inflammatory effects in the clinics. Our group work with doctors and researcher in Wuhan University and Harvard University to test the therapeutic potential of diammonium glycyrrhizinate, a glycyrrhetinic acid derivative, in COVID-19 therapy. We reported a severe case of non-hospitalized COVID-19 which received diammonium glycyrrhizinate as alternative medicine and eventually recovered. This case report is online today in Journal of Medical Virology.
April 25th, 2020
Dr. Huang collaborated with Dr. Feng Wu, and published an editorial article in Journal of Allergy and Clinical Immunology to discuss the strategies and SOP of diagnosing COVID-19. Dr. Feng Wu is a medical doctor in the Department of Critical Medicine, Southern Medical University, Guangzhou, Guangdong. She is one of the first doctors who volunteered to support Wuhan during the initial outbreak. Dr. Wu has been helping the world to better understand the epidemiological and clinical characteristics of COVID-19 and sharing precious experiences gained by doctors during the Wuhan emergency.
March 16th, 2020
The American Association of Immunologists had to cancel its annual meeting in Honolulu this May, due to COVID-19 pandemic. Huang lab has been preparing to attend the meeting with two selected oral presentations (by Dr. Natalie Nidetz and Mr. Michael McGee) and one block symposium co-chair (Dr. Weishan Huang), and is very sad about the situation. Cancellation is however a correct decision. We will continue to work on these projects and prepare to present them in IMMUNOLOGY 2021.
March 4th, 2020
Dr. Huang, as one of the ten Public Policy Fellows of the American Association of Immunologists (AAI), visited the Capitol Hill in Washington, D.C.. The AAI Public Policy Fellows and Public Affair committee members advocated for a predictable and sustained growth of the NIH budget for biomedical research. The AAI strongly supports the amount of at least $44.7 billion for NIH budget in FY2021, and an urgent supplemental bill to help combat COVID-19. As a constituent of the Louisiana State, Dr. Huang led the discussions with staffers in Representative Garret Graves, Senator John Kennedy, and Senator Bill Cassidy’s offices.
February 14th, 2020
Our lab received research funds from MegaRobo Technologies Co. today to further investigate signals that regulate immune homeostasis. We thank MegaRobo for the generous support.
February 12th, 2020
Congratulations to Jessica Elmore, Michael McGee, Dr. Natalie Nidetz and Orchi Anannya for publishing a meeting review on “Tuning T helper cell differentiation by ITK” , in Biochemical Society Transactions.
December 19th, 2019
In collaboration with Dr. David Russell and Dr. Avery August at Cornell University, we discovered that ITK signaling promotes early pulmonary protection against Mycobacterium tuberculosis infection. This work is accepted for publication in Frontiers In Immunology today.
December 16th, 2019
Our research proposal (R56AI146226) is selected by the National Institute of Allergy and Infectious Diseases as a High Priority, Short-Term Project Award. In this project, we aim to explore the “Heterogeneity and molecular signatures of therapeutic T cells in allergic airway inflammation” .
December 11th, 2019
Congratulations to Dr. Natalie Nidetz for publishing her review article on “Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery” . This manuscript is online today in Pharmacology & Therapeutics.
November 12th, 2019
In collaboration with Dr. Nooruddin Khan at University of Hyderabad in India and Dr. Avery August at Cornell University, we reported the finding that “Amino acid starvation enhances vaccine efficacy by augmenting neutralizing antibody production” . This work is published today in Science Signaling.
October 24th, 2019
Dr. Huang was invited to give a special seminar in the Department of Immunology, School of Basic Medical Sciences, at Peking University, to discuss “Regulatory T cells: Heterogeneity, Stability and Function” .
October 19th – 23rd, 2019
Dr. Huang was selected to give an oral presentation in The 17th International Congress of Immunology (IUIS 2019) conference in Beijing, China. She presented our lab’s recent findings that: “ITK regulates antigen-specific CD8+ T cell-derived IL-10 production and modulates influenza-induced pulmonary immunopathology” . Along with the opportunity to speak, Dr. Huang was also selected as an awardee of the AAI-IUIS Travel Grant.
July 31st, 2019
Dr. Huang gave an oral presentation to discuss “Heterogeneity of regulatory T cells in the mouse airway during influenza infection” in the Cornell Institute of Host-Microbe Interactions and Disease Summer Symposium.
July 7th– 12th, 2019
Dr. Huang presented her poster on ITK function in CD8+ T cell homeostasis in the Federation of American Societies for Experimental Biology (FASEB) Science Research Conference (SRC)- Autoimmunity and received a Poster Award from FASEB.
May 11th, 2019
Congratulations to Sabrina Solouki for publishing her first review article on “Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications” . This manuscript is online today in Pharmacology & Therapeutics.
May 9th – 13th, 2019
Dr. Huang was selected to give a talk and present a poster in the IMMUNOLOGY 2019 conference in San Diego, CA. Her seminar title was: “ITK regulates antigen-specific CD8+ T cell-derived IL-10 production and modulates influenza-induced pulmonary immunopathology” . Along with the opportunity to speak, Dr. Huang was also selected as one of the faculty awardees of the AAI Early Career Faculty Travel Grant.
May 7th, 2019
Michael McGee presented his work-in-progress on signaling regulation of type 1 regulatory T cell development, and won the 3rd place award for his oral presentation in The 15th Annual Pathobiological Science Graduate Student Symposium. Congratulations Michael!
May 1st, 2019
Dr. Huang was selected to participate in The AAI Public Policy Fellows Program (PPFP) (2019-2020). The PPFP provides early-career researchers, who are committed to a career in biomedical research, with the opportunity to learn about and participate in the public policy and legislative activities of AAI. As an AAI PPFP fellow, Dr. Huang will receive training by representatives of the AAI and Congress, attend the AAI-2019 meeting in San Diego, and communicate with staff of the AAI Office of Public Policy and Government Affairs on public policy.
April 6th, 2019
Dr. Huang was selected to give an oral presentation in The 7th Annual Conference on Computational Biology & Bioinformatics of the Louisiana Biomedical Research Network, to discuss the “Heterogeneity of regulatory T cells in the mouse airway during influenza infection”.
February 28th, 2019
HDAC11 is the known smallest histone deacetylase, and has been reported with immunomodulatory function, but its mechanism was unclear. Dr. Hening Lin at Cornell University and Dr. Ji Cao at Zhejiang University discovered that HDAC11 catalyzes defatty-acylation of SHMT2 to modulate the stability of type I interferon receptor on the cell surface. Dr. Huang contributed to determining the levels of membrane IFNaR1 in HDAC11-deficient cells during innate immune stimulation. This finding was published online today in Proceedings of the National Academy of Sciences of the United States of America (PNAS).
January 14th, 2019
Thymic Foxp3+ regulatory T (tTreg) cells are critical modulators of the immune homeostasis. Led by Dr. Farrar at University of Minnesota, a collaborative team including Dr. Huang at LSU, and others at Medical College of Wisconsin, University of California San Francisco, Cornell University, University of Chicago, University of California Berkeley, and the Salk Institute reported two distinct thymic programs through which tTreg cells develop. This article was published online today in Nature Immunology.
January 2nd, 2019
Congratulations to the Center For Lung Biology and Disease in the Department of Pathobiological Sciences at Louisiana State University for receiving a COBRE program award (P20 GM130555) from the National Institute of General Medical Sciences. The Huang lab is part of the research team to investigate the regulatory immune mechanisms during influenza-induced pulmonary pathogenesis.
December 10th, 2018
Congratulations to our Graduate Student Michael McGee for being selected by the American Association of Immunologists Travel for Techniques Award. Michael will spend a week visiting Dr. Charles Danko’s laboratory at Cornell University, to learn Precision nuclear Run-On & sequencing (PRO-seq) and Chromatin Run-On & sequencing (ChRO-seq). These techniques are extremely powerful in revealing real-time transcriptional activities, and we aim to learn and use these tools to dissect and understand the transcriptional regulatory landscape that regulates T cell fate programing.
November 5th, 2018
Our invention on “Novel Method for the Generation, Expansion, and Maintenance of Type-1 Regulatory T Cells” by utilizing the RAS signaling activity is posted by the Center for Technology Licensing at Cornell University today.
October 25th, 2018
Our article discussing the efficiency and fidelity of LAG3/CD49b co-expression as the molecular signature of type 1 regulatory T cells is accepted for publication in Frontiers In Immunology, as a selected original research in the Research Topic “T Cell Differentiation and Function in Tissue Inflammation” .
September 2nd -5th, 2018
Dr. Huang received the AAI-ECI2018 travel grant from the American Association of Immunologists to attend The 5th European Congress of Immunology conference in Amsterdam, Netherlands. Dr. Huang presented a poster on the role of ITK/TCR signaling in tuning CD8+ T cell homeostatic proliferation, and served as a Chairperson of the Poster Session “Initiation of Immune Responses”.
August 18th, 2018
Dr. Huang was invited to give a talk to discuss “Signaling regulation of memory CD8+ T cell homeostasis” in the Major Symposium of the 5th annual conference of the Asia-Pacific Association of Medicine and Bio-Immunology.
July 26th, 2018
Dr. Huang gave an oral presentation on “Regulatory T cells in the mucosal interface of host-pathogen interactions” in the Cornell Institute of Host-Microbe Interactions and Disease Summer Symposium.
July 12th, 2018
Our pilot research program on “ITK signaling in type 2 innate lymphoid cell-mediated pulmonary inflammation and fibrosis” is funded by The Competitive Research Program (CORP) funds released this year by the School of Veterinary Medicine at Louisiana State University.
June 26th, 2018
Dr. Huang presented in the Cornell–Ithaca and Weill Cornell Medicine community inter-campus Immunology Symposium to discuss “TCR/ITK signaling via mTOR tunes CD8+ T cell homeostatic proliferation, metabolism, and anti-tumor effector function” .
June 15th, 2018
Our collaborative project with Dr. Avery August at Cornell University to develop and investigate “A novel murine model of allergic airway inflammation” (1R21AI138497-01A1) is funded by the NIH! We are proud to be a part of the joint effort in studying the development and regulation of immunopathology in the airway.
June 12th, 2018
Our research proposal entitled “GCN2 signaling in pathogenic and regulatory T cell development in allergic airway inflammation” (1R21AI137822-01) is funded by the NIH! Cheers~
May 31st, 2018
The Huang lab proposal entitled “T cell signals in immune balance and host survival during T. gondii infection” is funded by the LSU Center for Experimental Infectious Diseases and Research, as a Pilot Research Program of the Parent Award 5P30GM110760 sponsored by the NIH:NIGMS Center for Biomedical Research Excellence (COBRE) mechanism.
May 14th – June 1st 2018
Dr. Huang was selected as a faculty scholar of the Summer Institute on the Future of Graduate Studies, by the Graduate School of Louisiana State University. This summer program provides an overview of central issues in graduate education, and a historical and structural frame for thinking about those issues. Attending scholars will study preliminary reports and recommendations made by Education Mentors*, to further develop their leadership in curricular and programmatic initiatives that will work together with LSU’s Strategic Plan of Graduate Studies.
* Stacia L. Haynie, Sasha Thackaberry, Chris M. Golde, Richard J. Koubek, Jane W. Cassidy.
May 4th – 8th, 2018
Dr. Huang was selected to give a talk and present a poster in the IMMUNOLOGY 2018 conference in Austin, TX. Her seminar title was: “The TCR/ITK signaling pathway regulates the counterbalance of effector and regulatory T cell development” . Along with the opportunity to speak, Dr. Huang was also selected as one of the faculty awardees of the AAI Early Career Faculty Travel Grant.
April 5th, 2018
Our collaborative research with Dr. Nooruddin Khan’s lab at University of Hyderabad in India on “Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy” is now published online in PLoS Biology. Congratulations to Noor and the Hyderabad-Cornell team!
March 21st, 2018
Congratulations to our graduate student Sabrina (Nana) Solouki for being selected as one of the eight finalists in Cornell’s 4th annual 3-Minute Thesis (3MT) competition. Nana’s speech entitled “Vaccine builds army” got Honorable Mention and Nana got a dinner celebration 🙂
February 23rd, 2018
Dr. Huang presented in “Lunch and Science Seminar Series—Spring 2018” at LSU, to discuss “Signals regulating the development and function of regulatory T cells”.
January 16th, 2018
The Huang Laboratory is launched at Louisiana State University, with a collaborative research site at Cornell University! Welcome to the Huang Lab!
December 21st, 2017
The August-Huang collaborative research proposal entitled “Itk Signaling and Type 1 Regulatory T Cell Differentiation and Function in Allergic Airway Inflammation” is funded (1R21AI129422-01A1)!